Choice of sclerosant: Experimental study

The sclerosant hydroxy polyethoxy dodecane (HDP) was studied in rats, and the results were compared with those from a previous study of tetradecyl sulphate of sodium (TSS).

Abstract:

There appeared to be no significant difference between the two. The sclerosant efficiency increases with increasing concentration up to 6%, but a higher concentration that 6% in un-likely to be more effective in the rat or in man. In man, good results probably depend on exposure on the endothelium to sclerosant undiluted with blood for 1 second, and the total volume of 6% HPD or 6% TSS at one visit, should not exceed 10ml.